Richard E. Hartman, PhD

Professor, Psychology

Contact Information

Email rhartman@llu.edu
Phone 909-558-8709
Fax 909-558-0171

Department of Psychology, Ste. 2 (upstairs)
Loma Linda University
11108 Anderson Street, Loma Linda, CA  92350

Hartman Behavioral Neuroscience Lab

Degree

• PhD, Behavior, Brain and Cognition - Washington University, St. Louis, 2001 

Areas of Specialization

• Behavioral neuroscience
• Experimental psychology

Professional Memberships

• American Association for the Advancement of Science
• International Behavioral and Neural Genetics Society
• Oxygen Club of California
• Society for Neuroscience

Recent Publications​

• Jullienne A, Hamer M, Haddad E, Morita A, Gifford P, Hartman R, Pearce WJ, Tang J, Zhang JH, Obenaus A. Acute intranasal osteopontin treatment in male rats following TBI increases the number of activated microglia but does not alter lesion characteristics. J Neurosci Res. 2019 Mar 20. doi: 10.1002/jnr.24405. PMID: 30892744.
• Bajwa NM, Lee JB, Halavi S, Hartman RE, Obenaus A. Repeated isoflurane in adult male mice leads to acute and persistent motor decrements with long-term modifications in corpus callosum microstructural integrity. J Neurosci Res. 2019 Mar;97(3):332-345. doi: 10.1002/jnr.24343. PMID: 30394562.
• Maloney SE, Creeley C, Hartman RE, Yuede CM, Zorumski CF, Jevtovic-Todorovic V, Dikranian K, Noguchi KK, Farber NB, Wozniak DF. Using animal models to evaluate the functional consequences of anesthesia during early neurodevelopment. Neurobiol Learn Mem. 2018 Mar 14. pii: S1074-7427(18)30068-6. doi: 10.1016/j.nlm.2018.03.014. PubMed PMID: 29550366.
• Bellone JA, Murray JR, Jorge P, Fogel TG, Kim M, Wallace DR, Hartman RE. Pomegranate supplementation improves cognitive and functional recovery following ischemic stroke: A randomized trial. Nutr Neurosci. 2018 Feb 13:1-6. doi: 10.1080/1028415X.2018.1436413. PubMed PMID: 29433376.
• Wan W, Ding Y, Xie Z, Li Q, Yan F, Budbazar E, Pearce WJ, Hartman R, Obenaus A, Zhang JH, Jiang Y, Tang J. PDGFR-β modulates vascular smooth muscle cell phenotype via IRF-9/SIRT-1/NF-κB pathway in subarachnoid hemorrhage rats. J Cereb Blood Flow Metab. 2018 Jan 1:271678X18760954. doi: 10.1177/0271678X18760954. PubMed PMID: 29480757.
• Hartman RE, Ross DM. Effects and mechanisms of actions of phytochemicals on Alzheimer's disease neuropathology. Front Biosci (Elite Ed). 2018 Jan 1;10:300-333. PubMed PMID: 28930620.
• Rudobeck E, Bellone JA, Szücs A, Bonnick K, Mehrotra-Carter S, Badaut J, Nelson GA, Hartman RE, Vlkolinský R. Low-dose proton radiation effects in a transgenic mouse model of Alzheimer’s Disease – Implications for space travel. PLoS One (2017).
• Zhang JH, Obenaus A, Liebeskind DS, Tang J, Hartman R, Pearce WJ. Recanalization, reperfusion, and recirculation in stroke. J Cereb Blood Flow Metab. 2017 Jan 1:271678X17732695. doi: 10.1177/0271678X17732695. [Epub ahead of print] PubMed PMID: 28925323.
• Manaenko A, Yang P, Nowrangi D, Budbazar E, Hartman RE, Obenaus A, Pearce WJ, Zhang JH, Tang J. Inhibition of stress fiber formation preserves blood-brain barrier after intracerebral hemorrhage in mice. J Cereb Blood Flow Metab. 2016 Nov 18. pii: 0271678X16679169. [Epub ahead of print] PubMed PMID: 27864464.
• Yang P, Manaenko A, Xu F, Miao L, Wang G, Hu X, Guo ZN, Hu Q, Hartman RE, Pearce WJ, Obenaus A, Zhang JH, Chen G, Tang J. Role of PDGF-D and PDGFR-β in neuroinflammation in experimental ICH mice model. Exp Neurol. 2016 Sep;283(Pt A):157-64. doi: 10.1016/j.expneurol.2016.06.010. PubMed PMID: 27302678.
• Li Y, Ma Q, Dasgupta C, Halavi S, Hartman RE, Xiao D, Zhang L. Inhibition of DNA Methylation in the Developing Rat Brain Disrupts Sexually Dimorphic Neurobehavioral Phenotypes in Adulthood. Mol Neurobiol. 2016 Jun 16. [Epub ahead of print] PubMed PMID: 27311770.
• Yang P, Wu J, Miao L, Manaenko A, Matei N, Zhang Y, Xu L, Pearce WJ, Hartman RE, Obenaus A, Zhang JH, Xu F, Tang J. Platelet-Derived Growth Factor Receptor-β Regulates Vascular Smooth Muscle Cell Phenotypic Transformation and Neuroinflammation After Intracerebral Hemorrhage in Mice. Crit Care Med. 2016 Jun;44(6):e390-402. doi: 10.1097/CCM.0000000000001425. PubMed PMID: 26646459; PubMed Central PMCID: PMC4868636.
• Wu J, Zhang Y, Yang P, Enkhjargal B, Manaenko A, Tang J, Pearce WJ, Hartman R, Obenaus A, Chen G, Zhang JH. Recombinant Osteopontin Stabilizes Smooth Muscle Cell Phenotype via Integrin Receptor/Integrin-Linked Kinase/Rac-1 Pathway After Subarachnoid Hemorrhage in Rats. Stroke. 2016 May;47(5):1319-27. doi: 10.1161/STROKEAHA.115.011552. PubMed PMID: 27006454; PubMed Central PMCID: PMC4846549.
• Ma Q, Dasgupta C, Li Y, Bajwa NM, Xiong F, Harding B, Hartman R, Zhang L. Inhibition of microRNA-210 provides neuroprotection in hypoxic-ischemic brain injury in neonatal rats. Neurobiol Dis. 2016 May;89:202-12. doi: 10.1016/j.nbd.2016.02.011. PubMed PMID: 26875527; PubMed Central PMCID: PMC4785034.
• Bajwa NM, Halavi S, Hamer M, Semple BD, Noble-Haeusslein LJ, Baghchechi M, Hiroto A, Hartman RE, Obenaus A. Mild Concussion, but Not Moderate Traumatic Brain Injury, Is Associated with Long-Term Depression-Like Phenotype in Mice. PLoS One. 2016 Jan 21;11(1):e0146886. doi: 10.1371/journal.pone.0146886. PubMed PMID: 26796696; PubMed Central PMCID: PMC4721654.
• Li Y, Ma Q, Halavi S, Concepcion K, Hartman RE, Obenaus A, Xiao D, Zhang L. Fetal stress-mediated hypomethylation increases the brain susceptibility to hypoxic-ischemic injury in neonatal rats. Exp Neurol. 2016 Jan;275 Pt 1:1-10. doi: 10.1016/j.expneurol.2015.10.007. PubMed PMID: 26597542; PubMed Central PMCID: PMC4688116.
• Hartman RE, Thorndyke EC 3rd. Patterns of Behavioral Deficits in Rodents Following Brain Injury Across Species, Gender, and Experimental Model. Acta Neurochir Suppl. 2016;121:71-5. doi: 10.1007/978-3-319-18497-5_12. PubMed PMID: 26463925.
• Bellone JA, Rudobeck E, Hartman RE, Szücs A, Vlkolinský R. A Single Low Dose of Proton Radiation Induces Long-Term Behavioral and Electrophysiological Changes in Mice. Radiat Res. 2015 Jul 24. [Epub ahead of print] PubMed PMID: 26207690.
• Baerresen KM, Miller KJ, Hanson ER, Miller JS, Dye RV, Hartman RE, Vermeersch D, Small GW. Neuropsychological tests for predicting cognitive decline in older adults. Neurodegener Dis Manag. 2015 Jun;5(3):191-201. PubMed PMID: 26107318.
• Karain B, Xu D, Bellone JA, Hartman RE, Shi WX. Rat globus pallidus neurons: functional classification and effects of dopamine depletion. Synapse. 2015 Jan;69(1):41-51. doi: 10.1002/syn.21783. Epub 2014 Sep 19. PubMed PMID: 25196543.
• Milner E, Holtzman JC, Friess S, Hartman RE, Brody DL, Han BH, Zipfel GJ. Endovascular perforation subarachnoid hemorrhage fails to cause Morris water maze deficits in the mouse. J Cereb Blood Flow Metab. 2014 Sep;34(9). doi: 10.1038/jcbfm.2014.108. Epub 2014 Jun 18. PubMed PMID: 24938403; PubMed Central PMCID: PMC4158664.
• Manaenko A, Lekic T, Barnhart M, Hartman R, Zhang JH. Inhibition of transforming growth factor-β attenuates brain injury and neurological deficits in a rat model of germinal matrix hemorrhage. Stroke. 2014 Mar;45(3):828-34. doi: 10.1161/STROKEAHA.113.003754. Epub 2014 Jan 14. PubMed PMID: 24425124; PubMed Central PMCID: PMC3966308.
• Ashwal S, Ghosh N, Turenius CI, Dulcich M, Denham CM, Tone B, Hartman R, Snyder EY, Obenaus A. Reparative effects of neural stem cells in neonatal rats with hypoxic-ischemic injury are not influenced by host sex. Pediatr Res. 2014 May;75(5):603-11. doi: 10.1038/pr.2014.7. Epub 2014 Jan 24. PubMed PMID: 24463490.

Recent Presentations

• Nomothetic versus idiographic outcomes following subarachnoid hemorrhage, intracerebral hemorrhage, and traumatic brain injury, 17th International Conference on Brain Edema and Cellular Injury, Guangzhou, China, December 2017.
• Keynote speaker at 5th International Symposium on Food and Brain Health, Sultan Qaboos University, Oman, November 2017.
• Kalynovska N., Dulcich M.S., Bajwa N.M., Xu D.Y., Baylink, D.J., Hartman R.E. Proton irradiation and pomegranate supplementation can both increase proliferation of new cells in the mouse brain, Society for Neuroscience, Washington D.C., November 2017.
• Smith, A., Hartman R.E. Seizure-like activity in Bang-sensitive Drosophila is increased by GABAa receptor antagonists and decreased by ellagic acid. Society for Neuroscience, Washington D.C., November 2017.
• Tan, A., Morton, K., & Hartman, R.E. The relationship between dietary polyphenol intake and depressive symptoms, Western Psychological Association, Sacramento, CA. April 2017.
• Pomegranate treatment for repetitive mild brain insults. *A. M. Briseno, N. M. Bajwa, A. Obenaus, R. E. Hartman; Dept. of Psychology, Dept. of Pediatrics, Div. of Interdisciplinary Studies, Loma Linda Univ., Loma Linda, CA; Cell, Molecular, and Developmental Biol. Program, Univ. of California Riverside, Riverside, CA. 2016 Society for Neuroscience Conference.
• Effects of pomegranate supplementation on recovery following ischemic stroke: a randomized, placebo-controlled, double-blind trial. J. R. Murray, J. A. Bellone, P. Jorge, T. G. Fogel, M. Kim, D. Wallace, R. E. Hartman; Psychology, Loma Linda Univ., Riverside, CA; Loma Linda Univ., Loma Linda, CA; Physical Med. and Rehabil., Loma Linda Univ. Med. Ctr., Loma Linda, CA. 2016 Society for Neuroscience Conference.
• Mao XM, Pecaut MJ, Hartman R & Gridley DS. NADPH Oxidase and Neurovascular Stress following Unloading and/or Low-Dose Radiation. American Society for Gravitational and Space Research, 2016.
• Bellone J, Sanders K, Gifford P, Hartman RE, Mao XW. Long-term Behavioral Effects of Chronic Exposure to Low-dose Cobalt-57 Radiation and/or Simulated Microgravity. American Society for Gravitational and Space Research, 2015.
• Ashwal S, Hartman R, Ghosh N, Tone B, Tian HR, Snyder, EY, Obenaus A. Human Neural Stem Cell Improve Water Maze Learning after Rat Pup Moderate Ischemic Injury Without Affecting Injury Volume. Presented at the 43^rd Annual Meeting of the Child Neurology Society, Columbus, Ohio, October 22-25, 2014, Ann Neurology 76: 2014; Supplement 18; pS239.
• Sanders, K., Bellone, J. A., Montanari, R. G., Gifford, P., Hartman, R. E., & Mao, X. W. (2014). Behavioral response to combined exposure of simulated microgravity and radiation. Poster presented at the annual meeting of the American Society for Gravitational and Space Research in Pasadena, CA, and submitted to the Society for Neuroscience conference in Washington, D.C.
• S Ashwal, R Hartman, N Ghosh, B Tone, HR Tian, E Snyder, A Obenaus (2014) Human neural stem cells improve water maze learning after rat pup moderate ischemic injury without affecting injury volume. 43rd Annual Meeting of the Child Neurology Society.
• N Mistry, S Halavi, M Hamer, A Obenaus & RE Hartman (2014) The emergence of a depressive phenotype after mild concussions in the adult mouse. Society for Neuroscience meeting.
• K Sanders, J Bellone, R Montanari, P Gifford, R Hartman & XW Mao (2014) Behavioral response to combined exposure of simulated microgravity and radiation. Society for Neuroscience meeting.
• S Halavi, N Mistry, M Hamer, M Evans, B Semple, A Obenaus & R Hartman (2014) The effects of closed-head injury on scent-marking behaviors in mice. Society for Neuroscience meeting.
• C Ray, M Finlay, G Nelson & R Hartman (2014) Analysis and mapping of water maze search strategies in cobalt-60 irradiated rats. Society for Neuroscience meeting.
• PV Lorenzo, M Dulcich & R Hartman (2014) Water maze swim strategies of mice exposed to proton radiation and a pomegranate-enhanced diet. Society for Neuroscience meeting.

Community Engagement

• Classroom presentations about the brain, Temecula Valley School District (2006-present)