Professor, Psychology
Contact Information
Email rhartman@llu.edu
Phone 909-558-8709
Fax 909-558-0171
Department of Psychology, Ste. 2 (upstairs)
Loma Linda University
11108 Anderson Street, Loma Linda, CA 92350
Hartman Behavioral Neuroscience Lab
Degree
- PhD, Behavior, Brain and Cognition - Washington University, St. Louis, 2001
Areas of Specialization
- Behavioral neuroscience
- Experimental psychology
Professional Memberships
- American Association for the Advancement of Science
- International Behavioral and Neural Genetics Society
- Oxygen Club of California
- Society for Neuroscience
Recent Publications and Presentations
Publications
- Hartman RE, Nathan NH, Ghosh N, Pernia CD, Law J, Nuryyev R, Plaia A, Yusof A, Tone B, Dulcich M, Wakeman DR, Dilmac N, Niles WD, Sidman RL, Obenaus A, Snyder EY, Ashwal S. A Biomarker for Predicting Responsiveness to Stem Cell Therapy Based on Mechanism-of-Action: Evidence from Cerebral Injury. Cell Rep. 2020 May 12;31(6):107622. doi: 10.1016/j.celrep.2020.107622. PubMed PMID: 32402283.
- Tan A, Morton KR, Lee JW, Hartman RE, Lee G. Adverse childhood experiences and depressive symptoms: Protective effects of dietary flavonoids. J Psychosom Res. 2020 Feb 11;131:109957. doi: 10.1016/j.jpsychores.2020.109957. PubMed PMID: 32088426.
- Hartman RE, Patel D. Dietary Approaches to the Management of Autism Spectrum Disorders. Adv Neurobiol. 2020;24:547-571. doi: 10.1007/978-3-030-30402-7_19. PubMed PMID: 32006373.
- Knox-Concepcion KR, Figueroa JD, Hartman RE, Li Y, Zhang L. Repression of the Glucocorticoid Receptor Increases Hypoxic-Ischemic Brain Injury in the Male Neonatal Rat. Int J Mol Sci. 2019 Jul 16;20(14). doi: 10.3390/ijms20143493. PubMed PMID: 31315247; PubMed Central PMCID: PMC6678481.
- Jullienne A, Hamer M, Haddad E, Morita A, Gifford P, Hartman R, Pearce WJ, Tang J, Zhang JH, Obenaus A. Acute intranasal osteopontin treatment in male rats following TBI increases the number of activated microglia but does not alter lesion characteristics. J Neurosci Res. 2019 Mar 20. doi: 10.1002/jnr.24405. PMID: 30892744.
- Bajwa NM, Lee JB, Halavi S, Hartman RE, Obenaus A. Repeated isoflurane in adult male mice leads to acute and persistent motor decrements with long-term modifications in corpus callosum microstructural integrity. J Neurosci Res. 2019 Mar;97(3):332-345. doi: 10.1002/jnr.24343. PMID: 30394562.
- Maloney SE, Creeley C, Hartman RE, Yuede CM, Zorumski CF, Jevtovic-Todorovic V, Dikranian K, Noguchi KK, Farber NB, Wozniak DF. Using animal models to evaluate the functional consequences of anesthesia during early neurodevelopment. Neurobiol Learn Mem. 2018 Mar 14. pii: S1074-7427(18)30068-6. doi: 10.1016/j.nlm.2018.03.014. PubMed PMID: 29550366.
- Bellone JA, Murray JR, Jorge P, Fogel TG, Kim M, Wallace DR, Hartman RE. Pomegranate supplementation improves cognitive and functional recovery following ischemic stroke: A randomized trial. Nutr Neurosci. 2018 Feb 13:1-6. doi: 10.1080/1028415X.2018.1436413. PubMed PMID: 29433376.
- Wan W, Ding Y, Xie Z, Li Q, Yan F, Budbazar E, Pearce WJ, Hartman R, Obenaus A, Zhang JH, Jiang Y, Tang J. PDGFR-β modulates vascular smooth muscle cell phenotype via IRF-9/SIRT-1/NF-κB pathway in subarachnoid hemorrhage rats. J Cereb Blood Flow Metab. 2018 Jan 1:271678X18760954. doi: 10.1177/0271678X18760954. PubMed PMID: 29480757.
- Hartman RE, Ross DM. Effects and mechanisms of actions of phytochemicals on Alzheimer's disease neuropathology. Front Biosci (Elite Ed). 2018 Jan 1;10:300-333. PubMed PMID: 28930620.
- Rudobeck E, Bellone JA, Szücs A, Bonnick K, Mehrotra-Carter S, Badaut J, Nelson GA, Hartman RE, Vlkolinský R. Low-dose proton radiation effects in a transgenic mouse model of Alzheimer’s Disease – Implications for space travel. PLoS One (2017).
- Zhang JH, Obenaus A, Liebeskind DS, Tang J, Hartman R, Pearce WJ. Recanalization, reperfusion, and recirculation in stroke. J Cereb Blood Flow Metab. 2017 Jan 1:271678X17732695. doi: 10.1177/0271678X17732695. [Epub ahead of print] PubMed PMID: 28925323.
- Manaenko A, Yang P, Nowrangi D, Budbazar E, Hartman RE, Obenaus A, Pearce WJ, Zhang JH, Tang J. Inhibition of stress fiber formation preserves blood-brain barrier after intracerebral hemorrhage in mice. J Cereb Blood Flow Metab. 2016 Nov 18. pii: 0271678X16679169. [Epub ahead of print] PubMed PMID: 27864464.
- Yang P, Manaenko A, Xu F, Miao L, Wang G, Hu X, Guo ZN, Hu Q, Hartman RE, Pearce WJ, Obenaus A, Zhang JH, Chen G, Tang J. Role of PDGF-D and PDGFR-β in neuroinflammation in experimental ICH mice model. Exp Neurol. 2016 Sep;283(Pt A):157-64. doi: 10.1016/j.expneurol.2016.06.010. PubMed PMID: 27302678.
- Li Y, Ma Q, Dasgupta C, Halavi S, Hartman RE, Xiao D, Zhang L. Inhibition of DNA Methylation in the Developing Rat Brain Disrupts Sexually Dimorphic Neurobehavioral Phenotypes in Adulthood. Mol Neurobiol. 2016 Jun 16. [Epub ahead of print] PubMed PMID: 27311770.
- Yang P, Wu J, Miao L, Manaenko A, Matei N, Zhang Y, Xu L, Pearce WJ, Hartman RE, Obenaus A, Zhang JH, Xu F, Tang J. Platelet-Derived Growth Factor Receptor-β Regulates Vascular Smooth Muscle Cell Phenotypic Transformation and Neuroinflammation After Intracerebral Hemorrhage in Mice. Crit Care Med. 2016 Jun;44(6):e390-402. doi: 10.1097/CCM.0000000000001425. PubMed PMID: 26646459; PubMed Central PMCID: PMC4868636.
- Wu J, Zhang Y, Yang P, Enkhjargal B, Manaenko A, Tang J, Pearce WJ, Hartman R, Obenaus A, Chen G, Zhang JH. Recombinant Osteopontin Stabilizes Smooth Muscle Cell Phenotype via Integrin Receptor/Integrin-Linked Kinase/Rac-1 Pathway After Subarachnoid Hemorrhage in Rats. Stroke. 2016 May;47(5):1319-27. doi: 10.1161/STROKEAHA.115.011552. PubMed PMID: 27006454; PubMed Central PMCID: PMC4846549.
- Ma Q, Dasgupta C, Li Y, Bajwa NM, Xiong F, Harding B, Hartman R, Zhang L. Inhibition of microRNA-210 provides neuroprotection in hypoxic-ischemic brain injury in neonatal rats. Neurobiol Dis. 2016 May;89:202-12. doi: 10.1016/j.nbd.2016.02.011. PubMed PMID: 26875527; PubMed Central PMCID: PMC4785034.
- Bajwa NM, Halavi S, Hamer M, Semple BD, Noble-Haeusslein LJ, Baghchechi M, Hiroto A, Hartman RE, Obenaus A. Mild Concussion, but Not Moderate Traumatic Brain Injury, Is Associated with Long-Term Depression-Like Phenotype in Mice. PLoS One. 2016 Jan 21;11(1):e0146886. doi: 10.1371/journal.pone.0146886. PubMed PMID: 26796696; PubMed Central PMCID: PMC4721654.
- Li Y, Ma Q, Halavi S, Concepcion K, Hartman RE, Obenaus A, Xiao D, Zhang L. Fetal stress-mediated hypomethylation increases the brain susceptibility to hypoxic-ischemic injury in neonatal rats. Exp Neurol. 2016 Jan;275 Pt 1:1-10. doi: 10.1016/j.expneurol.2015.10.007. PubMed PMID: 26597542; PubMed Central PMCID: PMC4688116.
- Hartman RE, Thorndyke EC 3rd. Patterns of Behavioral Deficits in Rodents Following Brain Injury Across Species, Gender, and Experimental Model. Acta Neurochir Suppl. 2016;121:71-5. doi: 10.1007/978-3-319-18497-5_12. PubMed PMID: 26463925.
- Bellone JA, Rudobeck E, Hartman RE, Szücs A, Vlkolinský R. A Single Low Dose of Proton Radiation Induces Long-Term Behavioral and Electrophysiological Changes in Mice. Radiat Res. 2015 Jul 24. [Epub ahead of print] PubMed PMID: 26207690.
- Baerresen KM, Miller KJ, Hanson ER, Miller JS, Dye RV, Hartman RE, Vermeersch D, Small GW. Neuropsychological tests for predicting cognitive decline in older adults. Neurodegener Dis Manag. 2015 Jun;5(3):191-201. PubMed PMID: 26107318.
Presentations
- Nelson GA, Gangadharmath U, Jones T, Hartman RE, Gifford P. Radiation Effects on Synapse Number. Radiation Research Society.
- Holshouser B, Gangadharmath U, Hartman RE, Jones T, Eliamani S, Stanbouly S, Gifford P, Nelson GA. In vivo Synaptic Density Imaging with 18F-UCB-H Detects Effects of Space Irradiation in the Rat Brain. Society of Nuclear medicine and Molecular Imaging Conference.
- Assessing the behavioral effects of proton irradiation and polyphenol supplementation on a high throughput fruit fly model of traumatic brain injury. T. A. Togashi, A. D. Trofimova, C. Barcenas, W. Hardeman, M. Hanna, S. Loong, M. White, V. Watts, G. A. Nelson, R. E. Hartman. Society for Neuroscience Conference, Chicago, IL, October 2019.
- The behavioral effects of blocking PDGF-R in a rat model of traumatic brain injury. N. Kalynovska, M. Hamer, P. Gifford, A. Jullienne, J. Tang, W. Pearce, J. H. Zhang, A. Obenaus, R. E. Hartman. Society for Neuroscience Conference, Chicago, IL, October 2019.
- Identifying common and distinct behavioral phenotypes associated with 3 types of hemorrhagic brain injury in rats. W. Hardeman, M. Hamer, P. Gifford, J. Tang, W. Pearce, J. H. Zhang, A. Obenaus, R. E. Hartman. Society for Neuroscience Conference, Chicago, IL, October 2019.
- Exploring the physical and behavioral effects of a potassium channel antagonist in young adult male rats. A. D. Trofimova, P. S. Gifford, D. A. Hessinger, D. L. Bellinger, R. E. Hartman. Society for Neuroscience Conference, Chicago, IL, October 2019.
- Exploring the effects of prophylactic & therapeutic dietary polyphenol treatments on traumatic brain injury outcomes in Drosophila melanogaster. B. E. Tolan, A. D. Trofimova, R. E. Hartman. Society for Neuroscience Conference, Chicago, IL, October 2019.
- A preliminary strategy to provide further education to physicians and caregivers on the dietary approaches to the treatment of autism spectrum disorders. D. S. Patel, R. E. Hartman. Society for Neuroscience Conference, Chicago, IL, October 2019.
- Nomothetic versus idiographic outcomes following subarachnoid hemorrhage, intracerebral hemorrhage, and traumatic brain injury, 17th International Conference on Brain Edema and Cellular Injury, Guangzhou, China, December 2017.
- Keynote speaker at 5th International Symposium on Food and Brain Health, Sultan Qaboos University, Oman, November 2017.
- Kalynovska N., Dulcich M.S., Bajwa N.M., Xu D.Y., Baylink, D.J., Hartman R.E. Proton irradiation and pomegranate supplementation can both increase proliferation of new cells in the mouse brain, Society for Neuroscience Conference, Washington D.C., November 2017.
- Smith, A., Hartman R.E. Seizure-like activity in Bang-sensitive Drosophila is increased by GABAa receptor antagonists and decreased by ellagic acid. Society for Neuroscience Conference, Washington D.C., November 2017.
- Tan, A., Morton, K., & Hartman, R.E. The relationship between dietary polyphenol intake and depressive symptoms, Western Psychological Association, Sacramento, CA. April 2017.
- Pomegranate treatment for repetitive mild brain insults. A. M. Briseno, N. M. Bajwa, A. Obenaus, R. E. Hartman. Society for Neuroscience Conference, San Diego, CA, November 2016.
- Effects of pomegranate supplementation on recovery following ischemic stroke: a randomized, placebo-controlled, double-blind trial. J. R. Murray, J. A. Bellone, P. Jorge, T. G. Fogel, M. Kim, D. Wallace, R. E. Hartman. Society for Neuroscience Conference, San Diego, CA, November 2016.
- Mao XM, Pecaut MJ, Hartman R & Gridley DS. NADPH Oxidase and Neurovascular Stress following Unloading and/or Low-Dose Radiation. American Society for Gravitational and Space Research, 2016.
- Bellone J, Sanders K, Gifford P, Hartman RE, Mao XW. Long-term Behavioral Effects of Chronic Exposure to Low-dose Cobalt-57 Radiation and/or Simulated Microgravity. American Society for Gravitational and Space Research, 2015.
Community Engagement
- Classroom presentations about the brain, Temecula Valley School District (2006-present)